Facilities for optimizing and designing multiarm multistage (MAMS) randomized controlled trials with binary outcomes

Babak Choodari-Oskooei (), Daniel J. Bratton () and Mahesh K. B. Parmar ()
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Babak Choodari-Oskooei: MRC Clinical Trials Unit at UCL
Daniel J. Bratton: GlaxoSmithKline
Mahesh K. B. Parmar: MRC Clinical Trials Unit at UCL

Stata Journal, 2023, vol. 23, issue 3, 774-798

Abstract: We introduce two commands, nstagebin and nstagebinopt, that can be used to facilitate the design of multiarm multistage (MAMS) trials with binary outcomes. MAMS designs are a class of efficient and adaptive randomized clinical trials that have successfully been used in many disease areas, including cancer, tu- berculosis, maternal health, COVID-19, and surgery. The nstagebinopt command finds a class of efficient “admissible” designs based on an optimality criterion using a systematic search procedure. The nstagebin command calculates the stagewise sample sizes, trial timelines, and overall operating characteristics of MAMS designs with binary outcomes. Both commands allow the use of Dunnett’s correction to account for multiple testing. We also use the ROSSINI 2 MAMS design, an ongo- ing MAMS trial in surgical wound infection, to illustrate the capabilities of both commands. The new commands facilitate the design of MAMS trials with binary outcomes where more than one research question can be addressed under one protocol.

Keywords: nstagebin; nstagebinopt; multiarm multistage; MAMS; family-wise type I error rate; FWER; α functions; adaptive designs (search for similar items in EconPapers)
Date: 2023
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DOI: 10.1177/1536867X231196295

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