The Use of Generalized Estimating Equations for Risk Assessment in Developmental Toxicity

Louise Ryan

Risk Analysis, 1992, vol. 12, issue 3, 439-447

Abstract: This paper reviews and compares several approaches to fitting dose‐response models to developmental toxicity data. The main issue of interest is how to appropriately account for litter effects. Among the approaches reviewed are Beta Binomial models, models that attempt to characterize the litter effect through the use of covariates, and models that avoid the complication of correlated offspring by modeling “affected litter” rather than fetus‐specific outcomes. Finally, we discuss our recommended approach, which is to use Generalized Estimating Equations, or quasi‐likelihood. We give a number of reasons for preferring the latter and illustrate its application with an example.

Date: 1992
References: View complete reference list from CitEc
Citations: View citations in EconPapers (6)

Downloads: (external link)
https://doi.org/10.1111/j.1539-6924.1992.tb00696.x

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:wly:riskan:v:12:y:1992:i:3:p:439-447

Access Statistics for this article

More articles in Risk Analysis from John Wiley & Sons
Bibliographic data for series maintained by Wiley Content Delivery ().