Use of Biological Markers in Risk Assessment1

Alex McMillan, Alice S. Whittemore, Abraham Silvers and Yasamin DiCiccio

Risk Analysis, 1994, vol. 14, issue 5, 807-813

Abstract: Measurements of intermediate end points in the carcinogenic process may reduce uncertainty in human risk assessment from bioassay data, by identifying sources of interspecies variation and dose nonlinearity. This paper describes desirable properties of such markers: persistence, predictive power, temporal relevance, and consistency across dose rate and species. We illustrate these properties by evaluating markers for squamous cell nasal carcinoma in rodents exposed to formaldehyde. We also discuss design issues for bioassays that evaluate markers and tumors simultaneously at necropsy.

Date: 1994
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https://doi.org/10.1111/j.1539-6924.1994.tb00292.x

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Persistent link: https://EconPapers.repec.org/RePEc:wly:riskan:v:14:y:1994:i:5:p:807-813

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