A Nonidentifiability Aspect of the Two‐Stage Model of Carcinogenesis

Leonid G. Hanin and Andrej Yu. Yakovlev

Risk Analysis, 1996, vol. 16, issue 5, 711-715

Abstract: This paper discusses identifiability of the two‐stage birth‐death‐mutation model of carcinogenesis. It is shown that the homogeneous version of the model is nonidentifiable; the same is all the more evident for its nonhomogeneous versions. This result implies that the model parameters cannot be uniquely estimated from time‐to‐tumor observations.

Date: 1996
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https://doi.org/10.1111/j.1539-6924.1996.tb00819.x

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Persistent link: https://EconPapers.repec.org/RePEc:wly:riskan:v:16:y:1996:i:5:p:711-715

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