A Quantitative Analysis of Factors Affecting PELs and TLVs for Carcinogens

Jeffrey S. Smith and John M. Mendeloff

Risk Analysis, 1999, vol. 19, issue 6, 1223-1224

Abstract: For carcinogens, this paper provides a quantitative examination of the roles of potency and weight‐of‐evidence (WOE) in setting permissible exposure limits (PELs) at the U.S. Occupational Safety and Health Administration (OSHA) and threshold limit values (TLVs) at the private American Conference of Governmental Industrial Hygienists (ACGIH). On normative grounds, both of these factors should influence choices about the acceptable level of exposures. Our major objective is to examine whether and in what ways these factors have been considered by these organizations. A lesser objective is to identify outliers, which might be candidates for further regulatory scrutiny. Our sample (N=48) includes chemicals for which EPA has estimated a unit risk as a measure of carcinogenic potency and for which OSHA or the ACGIH has a PEL or TLV. Different assessments of the strength of the evidence of carcinogenicity were obtained from EPA, ACGIH, and the International Agency for Research on Cancer. We found that potency alone explains 49% of the variation in PELs and 62% of the variation in TLVs. For the ACGIH, WOE plays a much smaller role than potency. TLVs set by the ACGIH since 1989 appear to be stricter than earlier TLVs. We suggest that this change represents evidence that the ACGIH had responded to criticisms leveled at it in the late 1980s for failing to adopt sufficiently protective standards. The models developed here identify 2‐nitropropane, ethylene dibromide, and chromium as having OSHA PELs significantly higher than predicted on the basis of potency and WOE.

Date: 1999
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https://doi.org/10.1111/j.1539-6924.1999.tb01141.x

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Persistent link: https://EconPapers.repec.org/RePEc:wly:riskan:v:19:y:1999:i:6:p:1223-1224

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