Cancer Risk Estimation for Mixtures of Coal Tars and Benzo(a)pyrene

D. W. Gaylor, S. J. Culp, L. S. Goldstein and F. A. Beland

Risk Analysis, 2000, vol. 20, issue 1, 81-86

Abstract: Two‐year chronic bioassays were conducted by using B6C3F1 female mice fed several concentrations of two different mixtures of coal tars from manufactured gas waste sites or benzo(a)pyrene (BaP). The purpose of the study was to obtain estimates of cancer potency of coal tar mixtures, by using conventional regulatory methods, for use in manufactured gas waste site remediation. A secondary purpose was to investigate the validity of using the concentration of a single potent carcinogen, in this case benzo(a)pyrene, to estimate the relative risk for a coal tar mixture. The study has shown that BaP dominates the cancer risk when its concentration is greater than 6,300 ppm in the coal tar mixture. In this case the most sensitive tissue site is the forestomach. Using low‐dose linear extrapolation, the lifetime cancer risk for humans is estimated to be: Risk

Date: 2000
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Persistent link: https://EconPapers.repec.org/RePEc:wly:riskan:v:20:y:2000:i:1:p:81-86

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