TCDD Exposure‐Response Analysis and Risk Assessment

Hong Cheng, Lesa Aylward, Colleen Beall, Thomas B. Starr, Robert C. Brunet, Gaétan Carrier and Elizabeth Delzell

Risk Analysis, 2006, vol. 26, issue 4, 1059-1071

Abstract: We examined the relation between cancer mortality and time‐dependent cumulative exposure to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) estimated from a concentration‐ and age‐dependent kinetic model of elimination, and we estimated incremental cancer risks at age 75. Data from the National Institute for Occupational Safety and Health study of 3,538 workers with occupational exposure to TCDD were analyzed using standardized mortality ratios and Cox regression procedures. Analyses adjusted for potential confounding by age, year of birth, and race and considered exposure lag periods of 0, 10, or 15 years. Other potential confounders including smoking and other occupational exposures were evaluated indirectly. To explore the influence of extreme values of cumulative TCDD ppt‐years, we restricted the analysis to observations with exposure below the 95th percentile or used logarithmic (ln) transformed exposure values. We applied penalized smoothing splines to examine variation in the exposure‐response relation across the exposure range. TCDD was not statistically significantly associated with cancer mortality using the full data set, regardless of the lag period. When we restricted the analysis to observations with exposure below the 95th percentile, TCDD was associated positively with cancer mortality, particularly when a 15‐year lag was applied (untransformed exposure data: regression coefficient , standard error (s.e.) = 1.4 × 10−6, p

Date: 2006
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://doi.org/10.1111/j.1539-6924.2006.00800.x

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:wly:riskan:v:26:y:2006:i:4:p:1059-1071

Access Statistics for this article

More articles in Risk Analysis from John Wiley & Sons
Bibliographic data for series maintained by Wiley Content Delivery ().