On the Use of Hierarchical Probabilistic Models for Characterizing and Managing Uncertainty in Risk/Safety Assessment

Ralph L. Kodell and James J. Chen

Risk Analysis, 2007, vol. 27, issue 2, 433-437

Abstract: A general probabilistically‐based approach is proposed for both cancer and noncancer risk/safety assessments. The familiar framework of the original ADI/RfD formulation is used, substituting in the numerator a benchmark dose derived from a hierarchical pharmacokinetic/pharmacodynamic model and in the denominator a unitary uncertainty factor derived from a hierarchical animal/average human/sensitive human model. The empirical probability distributions of the numerator and denominator can be combined to produce an empirical human‐equivalent distribution for an animal‐derived benchmark dose in external‐exposure units.

Date: 2007
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https://doi.org/10.1111/j.1539-6924.2007.00895.x

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Persistent link: https://EconPapers.repec.org/RePEc:wly:riskan:v:27:y:2007:i:2:p:433-437

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