SOME HINTS ON OPEN READING FRAME STATISTICS — HOW ORF LENGTH DEPENDS ON SELECTION

Agnieszka Gierlik, Paweł Mackiewicz, Maria Kowalczuk, Stanisław Cebrat () and Mirosław R. Dudek
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Agnieszka Gierlik: Institute of Microbiology, University of Wrocław, ul. Przybyszewskiego 63/77, 54-148 Wrocław, Poland
Paweł Mackiewicz: Institute of Microbiology, University of Wrocław, ul. Przybyszewskiego 63/77, 54-148 Wrocław, Poland
Maria Kowalczuk: Institute of Microbiology, University of Wrocław, ul. Przybyszewskiego 63/77, 54-148 Wrocław, Poland
Stanisław Cebrat: Institute of Microbiology, University of Wrocław, ul. Przybyszewskiego 63/77, 54-148 Wrocław, Poland
Mirosław R. Dudek: Institute of Theoretical Physics, University of Wrocław, pl. Maxa Borna 9, 50-204 Wrocław, Poland

International Journal of Modern Physics C (IJMPC), 1999, vol. 10, issue 04, 635-643

Abstract: Coding sequences of DNA generate Open Reading Frames (ORFs) inside them with much higher frequency than random DNA sequences do, especially in the antisense strand. This is a specific feature of the genetic code. Since coding sequences are selected for their length, the generated ORFs are indirect results of this selection and their length is also influenced by selection. That is why ORFs found in any genome, even much longer ones than those spontaneously generated in random DNA sequences, should be considered as two different sets of ORFs: The first one coding for proteins, the second one generated by the coding ORFs. Even intergenic sequences possess greater capacity for generating ORFs than random DNA sequences of the same nucleotide composition, which seems to be a premise that intergenic sequences were generated from coding sequences by recombinational mechanisms.

Keywords: Open reading frame; Coding density; ORF generation; ORF length; Genetic code properties (search for similar items in EconPapers)
Date: 1999
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DOI: 10.1142/S0129183199000474

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