ANTIGEN RECOGNITION AND EVOLUTION IN A BIT-STRING POPULATION MODEL

Filippo Castiglione ()
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Filippo Castiglione: Center for Parallel Computing, University of Cologne, Weyertal 80, D-50931, Köln, Germany

International Journal of Modern Physics C (IJMPC), 1999, vol. 10, issue 06, 989-1002

Abstract: We present a simple model of selection and mutation of cell populations in the immune system. This is based on generic assumptions and in this respect it resembles a model for evolution in simple ecosystems. In this case the selection acts by means of the affinity function representing the ability of a certain class of lymphocytes to recognize a foreign antigen. Carrying out some analytical and numerical studies we determine the critical values for the parameters ruling the selection and mutation.

Keywords: Population dynamics; Molecular evolution; Bit-String models; Immune system (IS); Celada–Seiden model (CS-Model); Hypermutation (search for similar items in EconPapers)
Date: 1999
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DOI: 10.1142/S0129183199000796

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