BIOLOGICAL AGING — CRITERIA FOR MODELING AND A NEW MECHANISTIC MODEL

Scott D. Pletcher () and Claudia Neuhauser
Additional contact information
Scott D. Pletcher: Max Planck Institute of Demographic Research, Rostock, Germany
Claudia Neuhauser: School of Mathematics, University of Minnesota, Minneapolis, MN, USA

International Journal of Modern Physics C (IJMPC), 2000, vol. 11, issue 03, 525-546

Abstract: To stimulate interaction and collaboration across scientific fields, we introduce a minimum set of biological criteria that theoretical models of aging should satisfy. We review results of several recent experiments that examined changes in age-specific mortality rates caused by genetic and environmental manipulation. The empirical data from these experiments is then used to test mathematical models of aging from several different disciplines, including molecular biology, reliability theory, physics, and evolutionary biology/population genetics. We find that none of the current models are consistent with all of the published experimental findings. To provide an example of how our criteria might be applied in practice, we develop a new conceptual model of aging that is consistent with our observations.

Keywords: Mutation Accumulation; Evolution; Penna Model; Age-Specific Mortality; Redundancy Models (search for similar items in EconPapers)
Date: 2000
References: Add references at CitEc
Citations:

Downloads: (external link)
http://www.worldscientific.com/doi/abs/10.1142/S0129183100000444
Access to full text is restricted to subscribers

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:wsi:ijmpcx:v:11:y:2000:i:03:n:s0129183100000444

Ordering information: This journal article can be ordered from

DOI: 10.1142/S0129183100000444

Access Statistics for this article

International Journal of Modern Physics C (IJMPC) is currently edited by H. J. Herrmann

More articles in International Journal of Modern Physics C (IJMPC) from World Scientific Publishing Co. Pte. Ltd.
Bibliographic data for series maintained by Tai Tone Lim ().