A COOPERATIVE STOCHASTIC MODEL OF GENE EXPRESSION

Siddhartha Roy, Indrani Bose () and Subhrangshu Sekhar Manna
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Siddhartha Roy: Department of Biophysics, Bose Institute, P1/12, C.I.T. Scheme VII M, Calcutta-700054, India
Indrani Bose: Department of Physics, Bose Institute, 93/1, A.P.C. Road, Calcutta-700009, India
Subhrangshu Sekhar Manna: Satyendra Nath Bose National Centre for Basic Sciences, Block-JD, Sector-III, Salt Lake, Calcutta 700098, India

International Journal of Modern Physics C (IJMPC), 2001, vol. 12, issue 03, 413-420

Abstract: Recent experiments at the level of a single cell have shown that gene expression occurs in abrupt stochastic bursts. Further, in an ensemble of cells, the levels of proteins produced have a bimodal distribution. In a large fraction of cells, the gene expression is either off or has a high value. We propose a stochastic model of gene expression, the essential features of which are stochasticity and cooperative binding of RNA polymerase. The model can reproduce the bimodal behavior seen in experiments.

Keywords: Gene Expression; Stochastic Transcription; Bimodal Distribution (search for similar items in EconPapers)
Date: 2001
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DOI: 10.1142/S0129183101001821

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