MULTIPLE BASE SUBSTITUTION CORRECTIONS IN DNA SEQUENCE EVOLUTION

M. Kowalczuk, P. Mackiewicz, D. Szczepanik, A. Nowicka, M. Dudkiewicz, M. R. Dudek and S. Cebrat
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M. Kowalczuk: Institute of Microbiology, University of Wrocław, ul. Przybyszewskiego, 63/77, 54-148 Wrocław, Poland
P. Mackiewicz: Institute of Microbiology, University of Wrocław, ul. Przybyszewskiego, 63/77, 54-148 Wrocław, Poland
D. Szczepanik: Institute of Microbiology, University of Wrocław, ul. Przybyszewskiego, 63/77, 54-148 Wrocław, Poland
A. Nowicka: Institute of Microbiology, University of Wrocław, ul. Przybyszewskiego, 63/77, 54-148 Wrocław, Poland
M. Dudkiewicz: Institute of Microbiology, University of Wrocław, ul. Przybyszewskiego, 63/77, 54-148 Wrocław, Poland
M. R. Dudek: Institute of Physics, Pedagogical University of Zielona Góra, 65-069 Zielona Góra, Poland
S. Cebrat: Institute of Microbiology, University of Wrocław, ul. Przybyszewskiego, 63/77, 54-148 Wrocław, Poland

International Journal of Modern Physics C (IJMPC), 2001, vol. 12, issue 07, 1043-1053

Abstract: We discuss the Jukes and Cantor's one-parameter model and Kimura's two-parameter model unability to describe evolution of asymmetric DNA molecules. The standard distance measure between two DNA sequences, which is the number of substitutions per site, should include the effect of multiple base substitutions separately for each type of the base. Otherwise, the respective tables of substitutions cannot reconstruct the asymmetric DNA molecule with respect to the composition. Basing on Kimura's neutral theory, we have derived a linear law for the correlation of the mean survival time of nucleotides under constant mutation pressure and their fraction in the genome. According to the law, the corrections to Kimura's theory have been discussed to describe evolution of genomes with asymmetric nucleotide composition.We consider the particular case of the strongly asymmetricBorrelia burgdorferigenome and we discuss in detail the corrections, which should be introduced into the distance measure between two DNA sequences to include multiple base substitutions.

Keywords: DNA Evolution; Replication; Tables of Substitutions (search for similar items in EconPapers)
Date: 2001
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DOI: 10.1142/S0129183101002279

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