COMPOSITIONAL AND ENVIRONMENTAL DEPENDENCE OF THE STABILITY OF α-HELICES

Changjun Chen, Jianhui Feng, Linsen Zhang and Yi Xiao
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Changjun Chen: Biomolecular Physics and Modeling Group, Department of Physics, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China
Jianhui Feng: Biomolecular Physics and Modeling Group, Department of Physics, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China
Linsen Zhang: Biomolecular Physics and Modeling Group, Department of Physics, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China
Yi Xiao: Biomolecular Physics and Modeling Group, Department of Physics, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China

International Journal of Modern Physics C (IJMPC), 2005, vol. 16, issue 10, 1597-1608

Abstract: The stability of α-helices in proteins depends on both their compositions and environments. To see how these two factors match with each other, we selected three typical α-helices from real proteins each of them has different compositions of hydrophobic and hydrophilic amino acids. We simulated the dynamics of the three helices in vacuum and in water using molecular dynamics. The results show that the stabilities of the three α-helices are different in vacuum and in water, which are consistent with their locations in the proteins. We also found some interesting behaviors of these α-helices.

Keywords: Protein; α-helices; stability; molecular modeling (search for similar items in EconPapers)
Date: 2005
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DOI: 10.1142/S0129183105008187

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