HIV-1 STRATEGIES OF IMMUNE EVASION

F. Castiglione () and M. Bernaschi ()
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F. Castiglione: Istituto per le Applicazioni del Calcolo "M. Picone" (IAC), Consiglio Nazionale delle Ricerche (CNR), V.le del Policlinico, 137, 00161 Rome, Italy
M. Bernaschi: Istituto per le Applicazioni del Calcolo "M. Picone" (IAC), Consiglio Nazionale delle Ricerche (CNR), V.le del Policlinico, 137, 00161 Rome, Italy

International Journal of Modern Physics C (IJMPC), 2005, vol. 16, issue 12, 1869-1878

Abstract: We simulate the progression of the HIV-1 infection in untreated host organisms. The phenotype features of the virus are represented by the replication rate, the probability of activating the transcription, the mutation rate and the capacity to stimulate an immune response (the so-called immunogenicity).It is very difficult to studyin-vivoorin-vitrohow these characteristics of the virus influence the evolution of the disease. Therefore we resorted to simulations based on a computer model validated in previous studies.We observe, by means of computer experiments, that the virus continuously evolves under the selective pressure of an immune response whose effectiveness downgrades along with the disease progression. The results of the simulations show that immunogenicity is the most important factor in determining the rate of disease progression but, by itself, it is not sufficient to drive the disease to a conclusion in all cases.

Keywords: HIV-1; computer simulations; immunogenicity (search for similar items in EconPapers)
Date: 2005
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DOI: 10.1142/S0129183105008394

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