FLUCTUATIONS, ENVIRONMENT, MUTATIONS ACCUMULATION AND AGEING

Przemysław Biecek and Stanisław Cebrat
Additional contact information
Przemysław Biecek: Department of Genomics, Institute of Genetics and Microbiology, Wrocław University, ul. Przybyszewskiego 63/77, 51-148 Wroclaw, Poland
Stanisław Cebrat: Department of Genomics, Institute of Genetics and Microbiology, Wrocław University, ul. Przybyszewskiego 63/77, 51-148 Wroclaw, Poland

International Journal of Modern Physics C (IJMPC), 2006, vol. 17, issue 06, 923-931

Abstract: We present a model of evolution of the age structured population based on the Monte Carlo method. We have assumed that the health status of an individual is described by variance of its fluctuations. Each expressed deleterious mutation increases the fluctuations. Additionally, the fluctuations of the environment are superimposed on the fluctuations of individuals in the population. An individual dies if the combination of both stochastic processes trespass the limit (level of homeostasis) set as the model parameter.The genes are switched on chronologically, what leads to accumulating defective genes expressed during the late periods of life in the genetic pool of the population. That results in the specific age structured population, in accordance with the predictions of Medawar's hypothesis of ageing and the results of the Penna model simulations. A decrease of the variation of the environmental noise increases the average expected lifespan of individuals.

Keywords: Ageing; mutation accumulation; fluctuations; environment (search for similar items in EconPapers)
Date: 2006
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
http://www.worldscientific.com/doi/abs/10.1142/S0129183106009369
Access to full text is restricted to subscribers

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:wsi:ijmpcx:v:17:y:2006:i:06:n:s0129183106009369

Ordering information: This journal article can be ordered from

DOI: 10.1142/S0129183106009369

Access Statistics for this article

International Journal of Modern Physics C (IJMPC) is currently edited by H. J. Herrmann

More articles in International Journal of Modern Physics C (IJMPC) from World Scientific Publishing Co. Pte. Ltd.
Bibliographic data for series maintained by Tai Tone Lim ().