DEVELOPMENT OF A LATTICE BOLTZMANN FRAMEWORK FOR NUMERICAL SIMULATION OF THROMBOSIS

S. E. Harrison (), J. Bernsdorf (), D. R. Hose () and P. V. Lawford ()
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S. E. Harrison: Medical Physics and Clinical Engineering, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
J. Bernsdorf: C&C Research Laboratories, NEC Europe Ltd., Rathausallee 10, D-53757 Sankt Augustin, Germany
D. R. Hose: Medical Physics and Clinical Engineering, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
P. V. Lawford: Medical Physics and Clinical Engineering, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK

International Journal of Modern Physics C (IJMPC), 2007, vol. 18, issue 04, 483-491

Abstract: The interacting factors relating to thrombogenesis were defined by Virchow in 1856 to be abnormalities of blood chemistry, the vessel wall and haemodynamics. Together, these factors are known as Virchow's triad. Many attempts have been made to simulate numerically certain aspects of the complex phenomena of thrombosis, but a comprehensive model, which includes the biochemical and physical aspects of Virchow's triad, and is capable of predicting thrombus development within physiological geometries has not yet been developed. Such a model would consider the role of platelets and the coagulation cascade along with the properties of the flow in the chosen vessel.A lattice Boltzmann thrombosis framework has been developed, on top of an existing flow solver, to model the formation of thrombi resulting from platelet activation and initiation of the coagulation cascade by one or more of the strands of Virchow's triad. Both processes then act in parallel, to restore homeostasis as the deposited thrombus disturbs the flow. Results are presented in a model of deep vein thrombosis (DVT), resulting from hypoxia and associated endothelial damage.

Keywords: Blood clotting; lattice Boltzmann; deep vein thrombosis; 11.25.Hf; 123.1K (search for similar items in EconPapers)
Date: 2007
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DOI: 10.1142/S0129183107010711

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