EVIDENCE OF SCALE-FREE TOPOLOGY IN GENE REGULATORY NETWORK OF HUMAN TISSUES

M. Andrecut (), S. A. Kauffman and A. M. Madni
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M. Andrecut: Institute for Biocomplexity and Informatics, University of Calgary, 2500 University Drive NW, Calgary, Alberta, T2N 1N4, Canada
S. A. Kauffman: Institute for Biocomplexity and Informatics, University of Calgary, 2500 University Drive NW, Calgary, Alberta, T2N 1N4, Canada
A. M. Madni: Intelligent Systems Technology Inc., 3250 Ocean Park Blvd., Ste. 100, Santa Monica, CA 90405, USA

International Journal of Modern Physics C (IJMPC), 2008, vol. 19, issue 02, 283-290

Abstract: We report the reconstruction of the topology of gene regulatory network in human tissues. The results show that the connectivity of the regulatory gene network is characterized by a scale-free distribution. This result supports the hypothesis that scale-free networks may represent the common blueprint for gene regulatory networks.

Keywords: Gene regulatory networks; reverse engineering; mutual information; scale-free topology (search for similar items in EconPapers)
Date: 2008
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DOI: 10.1142/S0129183108012091

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