INFLUENCE OF A SMALL FRACTION OF INDIVIDUALS WITH ENHANCED MUTATIONS ON A POPULATION GENETIC POOL

S. Cebrat and D. Stauffer ()
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S. Cebrat: Department of Genomics, Wrocław University, ul. Przybyszewskiego 63/77, 51-148 Wrocław, Poland
D. Stauffer: Department of Genomics, Wrocław University, ul. Przybyszewskiego 63/77, 51-148 Wrocław, Poland

International Journal of Modern Physics C (IJMPC), 2009, vol. 20, issue 08, 1271-1279

Abstract: It has been observed that a higher mutation load could be introduced into the genomes of children conceived by assisted reproduction technology (fertilizationin-vitro). This generates two effects — slightly higher mutational pressure on the whole genetic pool of population and inhomogeneity of mutation distributions in the genetic pool. Computer simulations of the Penna ageing model suggest that already a small fraction of births with enhanced number of new mutations can negatively influence the whole population.

Keywords: Population genetics; ageing; Penna model; in-vitrofertilization (search for similar items in EconPapers)
Date: 2009
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DOI: 10.1142/S0129183109014333

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