POSITIVE FEEDBACK-ASSISTED SHORT/LONG-RANGE CELL SIGNALINGS IN MAPK CASCADES

Yanbin Zhang (), Kenian Chen, Junwei Wang, Aimin Chen and Tianshou Zhou
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Yanbin Zhang: College of Computer Science, Hangzhou Dianzi University, Hangzhou 310018, China
Kenian Chen: Department of Biotechnology, Guangzhou Medical College, Guangzhou 510180, China
Junwei Wang: School of Informatics, Guangdong University of Foreign Studies, Guangzhou 510006, China
Aimin Chen: School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, China
Tianshou Zhou: School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, China;

International Journal of Modern Physics C (IJMPC), 2009, vol. 20, issue 11, 1769-1787

Abstract: In this paper, we study potentials of positive feedback in spatial phosphoprotein signal propagation. For this, we consider a signaling pathway of four-tiered protein kinase cascades with each tier involving single (de)phosphorylation reactions only. In the case of a small cell, we propose a short positive feedback for short-range cell signaling, which can generate bistability to facilitate the phosphoprotein signal propagation from the plasma membrane to the periphery of cell nucleus. In contrast, in the case of a large cell for which the long-range signaling cannot be achieved by the short feedback, we propose a long positive feedback, and find that it can facilitate the propagation of phosphoprotein signal over a long distance. These results imply that positive-feedback mechanisms would be employed by living organisms for spatial information transfer and cellular decision-making processing.

Keywords: Mitogen-activated protein kinase cascades (MAPK cascades); short/long positive feedback; bistability; ultrasensitive; 87.15.R-; 87.16.Xa; 87.18.Mp; 87.18.Vf (search for similar items in EconPapers)
Date: 2009
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DOI: 10.1142/S0129183109014722

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