INFECTION SPREAD AND VIRUS RELEASEIN VITROIN CELL POPULATIONS AS A SYSTEM WITH PERCOLATION

Juan G. Diaz Ochoa ()
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Juan G. Diaz Ochoa: Otto-von-Guericke-Universität Magdeburg Universitätsplatz 2 Magdeburg, D-39106, Germany

International Journal of Modern Physics C (IJMPC), 2011, vol. 22, issue 03, 249-262

Abstract: The comprehension of the innate immune system of cell populations is not only of interest to understand systemsin vivobut alsoin vitro, for example, in the control of the release of viral particles for the production of vaccines. In this report I introduce a model, based on dynamical networks, that simulates the cell signaling responsible for this innate immune response and its effect on the infection spread and virus production. The central motivation is to represent a cell population that is constantly mixed in a bio-reactor where there is a cell-to-cell signaling of cytokines (which are proteins responsible for the activation of the antiviral response inside the cell). Such signaling allows the definition of clusters of linked immune cells. Additionally, depending on the density of links, it is possible to identify critical threshold parameters associated to a percolation phase transition. I show that the control of this antiviral response is equivalent to a percolation process.

Keywords: Cell-to-cell signaling; virus spreadin vitro; percolation; systems biology; 82.39.Rt; 87.18.Gh; 64.60.ah; 87.18.Vf; 05.50.+ (search for similar items in EconPapers)
Date: 2011
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DOI: 10.1142/S0129183111016191

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