Hodgkin–Huxley neurons with defective and blocked ion channels

James Christopher S. Pang () and Johnrob Y. Bantang ()
Additional contact information
James Christopher S. Pang: National Institute of Physics, University of the Philippines Diliman, Quezon City 1101, Philippines
Johnrob Y. Bantang: National Institute of Physics, University of the Philippines Diliman, Quezon City 1101, Philippines

International Journal of Modern Physics C (IJMPC), 2015, vol. 26, issue 10, 1-14

Abstract: We utilize the original Hodgkin–Huxley (HH) model to consider the effects of defective ion channels to the temporal response of neurons. Statistics of firing rate and inter-spike interval (ISI) reveal that production of action potentials (APs) in neurons is not sensitive to changes in membrane conductance for sodium and potassium ions, as well as to the reversal potential for sodium ions, as long as the relevant parameters do not exceed 13% from their normal levels. We also found that blockage of a critical fraction of either sodium or potassium channels (dependent on constant input current) respectively limits the firing activity or increases spontaneous spiking activity of neurons. Our model may be used to guide experiment designs related to ion channel control drug development.

Keywords: Hodgkin–Huxley neurons; ion channels; defect; 87.19.L; 87.16.Vy; 87.19.ll (search for similar items in EconPapers)
Date: 2015
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
http://www.worldscientific.com/doi/abs/10.1142/S0129183115501120
Access to full text is restricted to subscribers

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:wsi:ijmpcx:v:26:y:2015:i:10:n:s0129183115501120

Ordering information: This journal article can be ordered from

DOI: 10.1142/S0129183115501120

Access Statistics for this article

International Journal of Modern Physics C (IJMPC) is currently edited by H. J. Herrmann

More articles in International Journal of Modern Physics C (IJMPC) from World Scientific Publishing Co. Pte. Ltd.
Bibliographic data for series maintained by Tai Tone Lim ().