Non-Newtonian effects of blood on LDL transport inside the arterial lumen and across multi-layered arterial wall with and without stenosis

Amin Deyranlou, Hamid Niazmand, Mahmood-Reza Sadeghi and Yaser Mesri
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Amin Deyranlou: Department of Mechanical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran†Research Center for Biomedical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran
Hamid Niazmand: Department of Mechanical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran†Research Center for Biomedical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran
Mahmood-Reza Sadeghi: #x2021;Department of Biomedical Engineering, University of Isfahan, Isfahan, Iran
Yaser Mesri: Department of Mechanical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran†Research Center for Biomedical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran

International Journal of Modern Physics C (IJMPC), 2016, vol. 27, issue 01, 1-22

Abstract: Blood non-Newtonian behavior on low-density lipoproteins (LDL) accumulation is analyzed numerically, while fluid-multilayered arteries are adopted for nonstenotic and 30%–60% symmetrical stenosed models. Present model considers non-Newtonian effects inside the lumen and within arterial layers simultaneously, which has not been examined in previous studies. Navier–Stokes equations are solved along with the mass transport convection–diffusion equations and Darcy’s model for species transport inside the luminal flow and across wall layers, respectively. Carreau model for the luminal flow and the modified Darcy equation for the power-law fluid within arterial layers are employed to model blood rheological characteristics, appropriately. Results indicate that in large arteries with relatively high Reynolds number Newtonian model estimates LDL concentration patterns well enough, however, this model seriously incompetent for regions with low WSS. Moreover, Newtonian model for plasma underestimates LDL concentration especially on luminal surface and across arterial wall. Therefore, applying non-Newtonian model seems essential for reaching to a more accurate estimation of LDL distribution in the artery. Finally, blood flow inside constricted arteries demonstrates that LDL concentration patterns along the stenoses inside the luminal flow and across arterial layers are strongly influenced as compared to the nonstenotic arteries. Additionally, among four stenosis severity grades, 40% stenosis is prone to more LDL accumulation along the post-stenotic regions.

Keywords: Fluid-multilayered artery; low-density lipoprotein; non-Newtonian fluid; stenosis (search for similar items in EconPapers)
Date: 2016
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DOI: 10.1142/S0129183116500030

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