Two different modes of oscillation in a gene transcription regulatory network with interlinked positive and negative feedback loops

Rajesh Karmakar ()
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Rajesh Karmakar: Department of Physics, Ramakrishna Mission Vidyamandira, Belur Math, Howrah, Pin-711202, W.B., India

International Journal of Modern Physics C (IJMPC), 2016, vol. 27, issue 05, 1-10

Abstract: We study the oscillatory behavior of a gene regulatory network with interlinked positive and negative feedback loop. The frequency and amplitude are two important properties of oscillation. The studied network produces two different modes of oscillation. In one mode (mode-I), frequency of oscillation remains constant over a wide range of amplitude and in the other mode (mode-II) the amplitude of oscillation remains constant over a wide range of frequency. Our study reproduces both features of oscillations in a single gene regulatory network and shows that the negative plus positive feedback loops in gene regulatory network offer additional advantage. We identified the key parameters/variables responsible for different modes of oscillation. The network is flexible in switching between different modes by choosing appropriately the required parameters/variables.

Keywords: Gene transcription regulatory network; interlinked feedback loops; nonlinearity; super oscillator (search for similar items in EconPapers)
Date: 2016
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DOI: 10.1142/S012918311650056X

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