Leaching And Exposure Of Phthalates From Medical Devices; Health Impacts And Regulations

Shoaib Ahmed Hab, Farah N. Talpur (), Jameel Ahmed Baig, Hassan Imran Afridi and Marvi Kanwal Talpur
Additional contact information
Shoaib Ahmed Hab: National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan
Farah N. Talpur: National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan
Jameel Ahmed Baig: National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan
Hassan Imran Afridi: National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan
Marvi Kanwal Talpur: National Center of Excellence in Analytical Chemistry,

Environmental Contaminants Reviews (ECR), 2018, vol. 1, issue 2, 13-21

Abstract: Phthalates (PAEs) are widely used as plasticizers in medical devices to make polyvinyl chloride flexible and soft. However, PAEs can be leached out from plasticizers undesirably and can migrate within the material and end up with direct exposure to humans. Therefore, a number of studies have been conducted globally focusing on their leaching from medical devices like blood bags, infusion tubing, peritoneal dialysis bags and tubing, catheters etc. In current review an attempt is made to gather information related to leaching, exposure, health implication of PAEs along with the regulation used in different countries. Toxic health effects with the exposure of PAEs includes neurological effects, DNA damage, oxidative stress, asthma with negative impact on lungs, effects on reproductive system, liver impairment and gastrointestinal effects. In addition, leaching studies has shown the presence of DEHP about 31 – 34 % in peritoneal dialysis set like bags and tubing. DEHP leached out from medical apparatus depends upon temperature, storage time, amount of DEHP present in devices and shaking of device while in touched with medical solution. The exposure of plasticizers for pregnant hospitalised women and infants has also highlighted. In addition, PAEs alternates introduced in market are also discussed like Trioctyltrimellitate/tri-(2-ethylhexyl) trimellitate) along with various regulations regarding the use of PAEs in medical devices and other products. was poor.

Keywords: PAEs leaching; exposure; health implication Medical devices; PAEs alternatives; labeling issues (search for similar items in EconPapers)
Date: 2018
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://contaminantsreviews.com/download/7236/ (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:zib:zbnecr:v:1:y:2018:i:2:p:13-21

DOI: 10.26480/ecr.02.2018.13.21

Access Statistics for this article

Environmental Contaminants Reviews (ECR) is currently edited by Professor Dr Muhammad Aqeel Ashraf

More articles in Environmental Contaminants Reviews (ECR) from Zibeline International Publishing
Bibliographic data for series maintained by Zibeline International Publishing ( this e-mail address is bad, please contact ).