An Exposure–Response Threshold for Lung Diseases Caused by Crystalline Silica

Louis Anthony Cox
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Louis Anthony Cox: Cox Associates

Chapter Chapter 11 in Improving Risk Analysis, 2012, pp 311-335 from Springer

Abstract: Abstract This chapter further develops the concept of dose–response thresholds for exposure-related lung diseases, using crystalline silica as an example. It also discusses epidemiological evidence as well as biological evidence. For the sake of practitioners who may care more about such specific applications than about the more general theoretical framework of the preceding two chapters, this chapter is self-contained; it briefly summarizes the relevant biology and the alternative basins-of-attraction modeling framework as they apply specifically to crystalline silica.

Keywords: Reactive Oxygen Species; Chronic Obstructive Pulmonary Disease; Lung Cancer Risk; Response Threshold; Crystalline Silica (search for similar items in EconPapers)
Date: 2012
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DOI: 10.1007/978-1-4614-6058-9_11

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