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Difference-in-differences with a mediator

Yuhao Deng, Haoyu Wei and Zhongzhe Ouyang

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Abstract: Causal mediation analysis is a powerful tool for disentangling the total effect of a treatment into its direct effect on the outcome and its indirect effect mediated through an intermediate variable. However, in observational studies, confounding between treatment and potential outcomes typically renders the total and natural effects non-identifiable. In this work, we advance mediation analysis within the difference-in-differences framework. Under a mediator-adjusted parallel trends assumption and additional conditions, we demonstrate that natural indirect, direct, and total effects are identifiable in the treated group. We further derive efficient influence functions for these estimands, enabling the construction of multiply robust and nonparametrically efficient estimators. We establish the asymptotic properties of these estimators. Applying our methodology to data from the Job Corps Study, we find that job training significantly increases both short-term and long-term earnings, after controlling for the indirect effect through the proportion of weeks employed.

Date: 2026-04
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