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Therapeutic Translation of Genomic Science: Opportunities and limitations of GWAS

Manuel I. Hermosilla and Jorge A. Lemus

No 23989, NBER Working Papers from National Bureau of Economic Research, Inc

Abstract: Many scientists predicted a swift revolution in human therapeutics after the completion of the Human Genome Project (“HGP”). This revolution, however, has been slow to materialize in spite of the scientific advances. We investigate the role of biological complexity in slowing down this revolution. Our test relies on a disease-specific measure of biological complexity, constructed by drawing on insights from Network Medicine (Barabási et al., 2011). According to our measure, more complex diseases are associated with a larger number of genetic mutations—higher centrality in the Human Disease Network (Goh et al., 2007). With this measure in hand, we estimate the rate of translation of new science into early-stage drug innovation by focusing on a leading type of genetic epidemiological knowledge (Genome-Wide Association Studies), and employing standard methods for the measurement of R&D productivity. For less complex diseases, we find a strong and positive association between cumulative knowledge and the amount of innovation. This association weakens as complexity increases, becoming statistically insignificant at the extreme. Our results suggest that biological complexity is, in part, responsible for the slower-than-expected unfolding of the therapeutical revolution set in motion by the HGP.

JEL-codes: I1 L65 O30 (search for similar items in EconPapers)
New Economics Papers: this item is included in nep-hea
Date: 2017-11
Note: HC PR
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Published as Therapeutic Translation of Genomic Science: Opportunities and Limitations of GWAS , Manuel Hermosilla, Jorge Lemus. in Economic Dimensions of Personalized and Precision Medicine , Berndt, Goldman, and Rowe. 2019

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