A new combination testing methodology to identify accurate and economical point-of-care testing strategies

Sanjay Jain, Jónas Oddur Jónasson, Jean Pauphilet, Barnaby Flower, Maya Moshe, Gianluca Fontana, Sutharsan Satkunarajah, Richard Tedder, Myra McClure, Hutan Ashrafian, Paul Elliott, Wendy S Barclay, Christina Atchison, Helen Ward, Graham Cooke, Ara Darzi and Kamalini Ramdas

No 958, Economics Series Working Papers from University of Oxford, Department of Economics

Abstract: Current CDC guidelines suggest combining tests, noting that “performance of orthogonal testing algorithms has not been systematically evaluated” and highlighting discordant outcomes. Our methodology combines available LFIAs to meet desired accuracy criteria, by identifying testing possibility frontiers which encompass benchmarks, enabling cost savings. Our methodology applies equally to antigen testing and can greatly expand testing capacity through combining less accurate tests, especially for use cases needing quick, accurate tests, e.g., entry to public spaces such as airports, nursing homes or hospitals.

Date: 2021-06-16
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