Immune Networks Modeled by Replicator Equations

Peter F. Stadler, Peter Schuster and Alan S. Perelson

Working Papers from Santa Fe Institute

Abstract: In order to evaluate the role of idiotypic networks in the operation of the immune system a number of mathematical models have been formulated. Here we examine a class of B-cell models in which cell proliferation is governed by a non-negative, unimodal, symmetric response function {\it f(h)}, where the field {\it h} summarizes the effect of the network on a single clone. We show that by transforming into relative concentrations, the B-cell network on a single clone. We then show that when the total number of clones in a network is conserved, the dynamics of the network can be represented by the dynamics of a replicator equations. The number of equilibria and their stability are then characterized using methods developed for the study of second-order replicator equations. Analogies with standard Lotka-Voterra equations are also indicated. A particularly interesting result of our analysis is the fact that even though the immune network equations are not second-order, the number and stability of their equilibria can be obtained by a superposition of second-order replicator systems. As a consequence, the problem of finding all of the equilibrium points of the nonlinear network equations can be reduced to solving linear equations.

Date: 1993-07
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Persistent link: https://EconPapers.repec.org/RePEc:wop:safiwp:93-07-048

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