HIV-1 Dynamics In Vivo: Virion Clearance Rate, Infected Cell Lifespan, and Viral Generation Time

Alan S. Perelson, Avidan U. Neumann, Martin Markowitz, John M. Leonard and David D. Ho

Working Papers from Santa Fe Institute

Abstract: Using a new mathematical model to analyze a detailed set of viral load data collected from five infected patients after the administration of a potent inhibitor of HIV-1 protease, it was estimated that productively infected cells have, on average, a lifespan of 2.2 days (t[sub 1/2]=1.6 days) and that plasma virions have a mean lifespan of 0.3 days (t[sub 1/2]=0.24 days). The average total HIV-1 production was 10.3 x 10[super 9} virions per day, which is substantially higher than previous minimum estimates. Our results also suggest that the minimum duration of the HIV-1 life cycle in vivo is 1.2 days on average, and that the average HIV-1 generation time, defined as the time from release of a virion until it infects another cell and causes the release of a new generation of viral particles, is 2.6 days. These findings on viral dynamics provide not only a kinetic picture ofHIV-1 pathogenesis, but also the theoretical principles to guide treatment strategies.

Date: 1996-02
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