 Secondary Structure of the 3'-Non-Coding Region of Flavivirus GenomesSusanne Rauscher,
Christoph Flamm,
Christian W. Mandl,
Franz X. Heinz and
Peter F. Stadler
Working Papers from Santa Fe Institute Abstract: The prediction of the complete matrix of base pairing probabilities was applied to the 3' non-coding region (NCR) of flavivirus genomes. This approach identifies not only well-defined secondary structure elements but also regions of high structural flexibility. Flaviviruses, many of which are important human pathogenes, have a common genomic organization but exhibit a significant degree of RNA sequence diversity in the functionally important 3'-NCR. We demonstrate the presence of secondary structures shared by all flaviviruses as well as structural features that are characteristic for groups of viruses within the genus reflecting the established classification scheme. The significance of most of the predicted structures is corroborated by compensatory mutations. The availability of infectious clones for several flaviviruses will allow to assess the involvement of these structures in specific processes of the viral life cycle, such as replication and assembly. Keywords: developmental canalization; epigenetic system; epistatic gene interactions; gene networks; neutral mutations; transcriptional regulators (search for similar items in EconPapers) There are no downloads for this item, see the EconPapers FAQ for hints about obtaining it. Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:wop:safiwp:97-02-010 Access Statistics for this paper More papers in Working Papers from Santa Fe Institute Contact information at EDIRC. |
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