Viral RNA and Evolved Mutational Robustness

Andreas Wagner and Peter F. Stadler

Working Papers from Santa Fe Institute

Abstract: Many properties of organisms show great robustness against mutations. Whether this robustness is an evolved property or intrinsic to genetic systems is by and large unknown. An evolutionary origin of robustness would require a rethinking of key concepts in the field of molecular evolution, such as gene-specific neutral mutation rates, or the context-independence of deleterious mutations. We provide evidence that mutational robustness of the genome of RNA viruses to mutational changes in secondary structure has evolved.

Appears in Journal of Experimental Zoology285, pp. 119-127.

Keywords: Canalization; epigenetic landscapes; neutral evolution; RNA folding (search for similar items in EconPapers)
Date: 1999-02
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Persistent link: https://EconPapers.repec.org/RePEc:wop:safiwp:99-02-010

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