RNA Folding at Elementary Step Resolution

Christoph Flamm, Walter Fontana, Ivo L. Hofacker and Peter Schuster

Working Papers from Santa Fe Institute

Abstract: We study the stochastic folding kinetics of RNA sequences into secondary structures with a new algorithm based on the formation, dissociation, and the shifting of individual base pairs. We discuss folding mechanisms and the correlation between the barrier structure of the conformational landscape and the folding kinetics for a number of examples based on artificial and natural sequences, inculding the influence of base modification in tRNAs.

Keywords: RNA folding kinetics; foldability; conformational spaces; RNA secondary structure. (search for similar items in EconPapers)
Date: 1999-12
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Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:wop:safiwp:99-12-078

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