Dynamical analysis of antigen-driven T-cell infection model with multiple delays

M. Prakash, R. Rakkiyappan, A. Manivannan and Jinde Cao

Applied Mathematics and Computation, 2019, vol. 354, issue C, 266-281

Abstract: This paper is mainly concerned with an investigation of antigen-driven T-cell infection process through a mathematical model. Several mathematical models have been introduced in the literature in order to gain insights into the dynamics of the disease progression, however, the results considering the effect of multiple factors which include antigen-driven CD4 T-cell progress, latent infection stage, activation of CTLs response, role of antiretroviral therapies (ARTs) and possibilities of multiple time-delays during the infection process are not involved. Hence, the paper introduces a six-dimensional virus infection model by involving the above factors. Particularly, (i) the effect of activation of antigen-specific T-cells; (ii) the effect of the maturation of infected cells; (iii) effect of multiple time delays, that is, during the interaction between susceptible and infectious and during the activation of immune responses; which play a significant role in preventing and modulating the Human Immunodeficiency Virus (HIV). The main aim of the paper to analyze the local and global stability of the class of mathematical models regarding the effect of time delays which provides a better pathway to the infection progress. Finally, the overall contribution of the present work is listed as follows: (1) by constructing the suitable Lyapunov functional, the global stability of the intracellular delayed model is derived; (2) detailed Hopf-bifurcation analysis is discussed with respect to immune response delay. The numerical simulation is performed to validate the effectiveness and applicability of the theoretical predictions.

Keywords: HIV-1; Antiretroviral therapy; Lyapunov functional; Hopf bifurcation; Global stability (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (4)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:apmaco:v:354:y:2019:i:c:p:266-281

DOI: 10.1016/j.amc.2019.02.050

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