Inhibition Effects of Salvianolic Acid M and Rosmarinic Acid in Salvia deserta Schang on Human Aldose Reductase

Qian He, Jie Wu, Xinling Wang and Jian Yang

Asian Agricultural Research, 2019, vol. 11, issue 08

Abstract: [Objectives] This study aimed to investigate the inhibition effects of two chemical constituents in Salvia deserta Schang on human aldose reductase (AR). [Methods] The isolated salvianolic acid M and rosmarinic acid were prepared into different concentrations of solutions for in vitro enzyme kinetics experiments. [Results] Salvianolic acid M and rosmarinic acid had the strongest inhibition effects at the concentration of 1 g/L. [Conclusions] Salvianolic acid M and rosmarinic acid have inhibition effects on human aldose reductase. The IC50 of salvianolic acid M is 0.79 μg/mL, and that of rosmarinic acid is 1.13 μg/mL.

Keywords: Agribusiness (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:ags:asagre:299751

DOI: 10.22004/ag.econ.299751

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