New Insights of Neuromedin B and its Receptor NMBR Involvement in Immunity

Chunyu Li, Yijie Ma, Shimao Tian, Qianhui Wan, Mengyao Tang, Hongya Ning, Shujie Ma and Guihong Yang

Asian Agricultural Research, 2021, vol. 13, issue 06

Abstract: Neuromedin B (NMB) is a member of mammalian bombesin-like peptide family and almost all its potent biological actions take place exclusively through its receptor NMBR, which has been identified as a G-protein couple receptor with seven trans-membrane regions. NMB and NMBR represent an interesting signaling axis over which NMB/NMBR perform multiple biological activities, in particularly, they have been highlighted in the regulation of the immunology system. This review aims to provide a brief overview of the recent advancements in our understanding regarding the potential immunological functions of NMB and NMBR in cell proliferation, tumorigenesis, angiogenesis, neurogenic inflammation, anti-influenza A virus (IAV) infections, and briefly discusses the potential importance of these observations. All these implicated that targeting NMBR or developing analogues of NMB may represent a useful strategy for development of new anti-IAV agents.

Keywords: Agribusiness (search for similar items in EconPapers)
Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:ags:asagre:316957

DOI: 10.22004/ag.econ.316957

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