 Estimated autism risk and older reproductive ageM.D. King, C. Fountain, D. Dakhlallah and P.S. Bearman American Journal of Public Health, 2009, vol. 99, issue 9, 1673-1679 Abstract: Objectives. We sought to estimate the risk for autism associated with maternal and paternal age across successive birth cohorts. Methods. We linked birth records and autism diagnostic records from the California Department of Developmental Services for children born in California between 1992 and 2000 to calculate the risk associated with maternal and paternal age for each birth cohort as well as for the pooled data. Results. The categorical risks associated with maternal age over 40 years ranged from a high of 1.84 (95% confidence interval [CI]=1.37, 2.47) to a low of 1.27 (95% CI=0.95, 1.69). The risk associated with paternal age ranged from 1.29 (95% CI=1.03, 1.6) to 1.71 (95% CI=1.41, 2.08). Conclusions. Pooling data across multiple birth cohorts inflates the risk associated with paternal age. Analyses that do not suffer from problems produced by pooling across birth cohorts demonstrated that advanced maternal age, rather than paternal age, may pose greater risk. Future research examining parental age as a risk factor must be careful to avoid the paradoxes that can arise from pooling data, particularly during periods of social demographic change. Date: 2009 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:aph:ajpbhl:10.2105/ajph.2008.149021_4 Access Statistics for this article American Journal of Public Health is currently edited by Alfredo Morabia More articles in American Journal of Public Health from American Public Health Association |
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