The changing epidemiology of invasive bacterial infections in Massachusetts children, 1984 through 1991

A.M. Loughlin, C.D. Marchant and S.M. Lett

American Journal of Public Health, 1995, vol. 85, issue 3, 392-394

Abstract: Coincident with the licensure of Haemophilus influenzae b conjugate vaccines from 1987 to 1990, the incidence of meningitis and other invasive infections caused by H influenzae type b declined in Massachusetts children by 87% and 91%, respectively. By 1991, Neisseria meningitidis had replaced H influenzae b as the leading cause of bacterial meningitis, accounting for 57% of cases. During the period 1984 through 1991, serogroup C displaced serogroup B as the most common cause of N meningitidis disease. Streptococcus pneumoniae caused 92% of nonmeningitis invasive disease, with serogroups 14, 6, 19, 18, 4, 2.3, and 9 causing 94.5% of infections. These finding have implications for the development of additional polysaccharide-protein conjugate vaccines for the prevention of childhood infections.

Date: 1995
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Persistent link: https://EconPapers.repec.org/RePEc:aph:ajpbhl:1995:85:3:392-394_0

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