The Boston AIDS Survival Score (BASS): A multidimensional AIDS severity instrument

G.R. Seage , C. Gatsonis, J. Weissman, J. Haas, P. Cleary, F. Fowler, M.P. Massagli, V.E. Stone, D.E. Craven, H. Makadon, J. Goldberg, K. Coltin, K.S. Levin and A.M. Epstein

American Journal of Public Health, 1997, vol. 87, issue 4, 567-573

Abstract: Objectives. This study developed a new acquired immunodeficiency syndrome (AIDS) severity system by including diagnostic, physiological, functional, and sociodemographic factors predictive of survival. Methods. Three-hundred five persons with AIDS in Boston were interviewed; their medical records were reviewed and vital status ascertained. Results. Overall median (±SD) survival for the cohort from the first interview until death was 560 ± 14.4 days. The best model for predicting survival, the Boston AIDS Survival Score, included the Justice score (stage 2 relative hazard [RH] = 1.25, 95% confidence interval [CI] = 0.80, 1.96; stage 3 RH = 1.76. 95% CI = 1.15, 2.70), a newly developed opportunistic disease score (Boston Opportunistic Disease Survival Score; stage 2 RH = 1.35, 95% CI = 0.90, 2.02; stage 3 RH = 2.10, 95% CI = 1.38, 3.18), and measures of activities of daily living (any intermediate limitations, RH = 1.84, 95% CI = 1.05, 3.21; any basic limitations, RH = 2.60, 95% CI = 1.44, 4.69). This model had substantially greater predictive power (R 2 = .17, C statistic = .68) than the Justice score alone (R 2 = .09, C statistic = .61). Conclusions. Incorporating data on clinically important events and functional status into a physiologically based system can improve the prediction of survival with AIDS.

Date: 1997
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Persistent link: https://EconPapers.repec.org/RePEc:aph:ajpbhl:1997:87:4:567-573_2

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