A model for type I diabetes in an HIV-infected patient under highly active antiretroviral therapy

Joseph Páez Chávez, Karunia Putra Wijaya, Carla M.A. Pinto and Clara Burgos-Simón

Chaos, Solitons & Fractals, 2022, vol. 155, issue C

Abstract: Type 1 diabetes (T1D), previously known as juvenile diabetes or insulin-dependent diabetes, is an autoimmune disease characterized by the insufficient (or lack of) production of insulin by the pancreas. Insulin is crucial to maintain blood sugar at healthy levels. High blood sugar damages the body and causes a variety of symptoms, ranging from severe thirst, fatigue, to urinary infections. The cells responsible for the production of insulin are the β-cells. In T1D, these are killed by an abnormal response of the immune system. Specific clones of cytotoxic T-cells invade the pancreatic islets of Langerhans, and eliminate them.

Keywords: Type 1 diabetes (T1D); Human immunodeficiency virus (HIV); β-Cells; Highly-antiretroviral therapy (HAART) (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:eee:chsofr:v:155:y:2022:i:c:s0960077921010705

DOI: 10.1016/j.chaos.2021.111716

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