Multifractal analysis of the UV/VIS spectra of malignant ascites: Confirmation of the diagnostic validity of a clinically evaluated spectral analysis

Irini S. Reljin, Branimir D. Reljin, Milka L. Avramov-Ivić, Dušan V. Jovanović, Goran I. Plavec, Slobodan D. Petrović and Gordana M. Bogdanović

Physica A: Statistical Mechanics and its Applications, 2008, vol. 387, issue 14, 3563-3573

Abstract: Multifractal (MF) approach was applied for the analysis of ultraviolet/visible (UV/VIS) spectra as an independent confirmation of the diagnostic efficacy of UV/VIS spectral analysis of intraperitoneal fluids, ascites, taken from patients with a known clinical diagnosis. Recently, it was reported that from UV/VIS spectra differentiation of malignant from benign ascites is possible. Here, it was shown that by using MF analysis of UV/VIS spectra, the objective classification of UV/VIS spectra is possible. The applicability of UV/VIS analysis and MF classification of spectra were evaluated on N=68 cases, of which M=64 and B=4 were clinically confirmed as malignant and benign, respectively. The overall diagnostic efficacy was 89.71% when using on-line analysis of UV/VIS spectra (61 out of 68 samples were positively recognized: 58 malignant and 3 benign), and even 95.59% by using off-line MF classsification (65 out of 68 samples were classified correctly: 63 malignant and 2 benign). It can be inferred that UV/VIS spectral analysis of ascites, combined with MF analysis, could be suggested as a successful and safe screening method in the evaluation of intraperitoneal fluids.

Keywords: Ascites; Neoplasm; Medical diagnosis; UV/VIS spectroscopy; Fractals; Multifractal analysis (search for similar items in EconPapers)
Date: 2008
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Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:387:y:2008:i:14:p:3563-3573

DOI: 10.1016/j.physa.2008.02.029

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