Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility

R.A. Ramos, Jair Zapata, C.A. Condat and Thomas S. Deisboeck

Physica A: Statistical Mechanics and its Applications, 2013, vol. 392, issue 10, 2415-2425

Abstract: A mesoscopic model is used to describe the effects of lymphocyte activity on a growing tumor. The model yields novel insights into the tumor–immune system interaction. In particular, we found that the presence of a putative chemotactic messenger that helps guide the lymphocytes towards the tumor is not critical to elicit the anti-tumor effects of the immune system, while lymphocytes that block tumor cell migration contribute to limit cancer expansion and thus have a more significant therapeutic impact.

Keywords: Tumor model; Cancer growth; Immunotherapy; Lymphocytes; Cell blockade (search for similar items in EconPapers)
Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:392:y:2013:i:10:p:2415-2425

DOI: 10.1016/j.physa.2013.01.047

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