K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons

Dax A. Hoffman, Jeffrey C. Magee, Costa M. Colbert and Daniel Johnston ()
Additional contact information
Dax A. Hoffman: Baylor College of Medicine
Jeffrey C. Magee: Louisiana State University Medical Center
Costa M. Colbert: Baylor College of Medicine
Daniel Johnston: Baylor College of Medicine

Nature, 1997, vol. 387, issue 6636, 869-875

Abstract: Abstract Pyramidal neurons receive tens of thousands of synaptic inputs on their dendrites. The dendrites dynamically alter the strengths of these synapses and coordinate them to produce an output in ways that are not well understood. Surprisingly, there turns out to be a very high density of transient A-type potassium ion channels in dendrites of hippocampal CA1 pyramidal neurons. These channels prevent initiation of an action potential in the dendrites, limit the back-propagation of action potentials into the dendrites, and reduce excitatory synaptic events. The channels act to prevent large, rapid dendritic depolarizations, thereby regulating orthograde and retrograde propagation of dendritic potentials.

Date: 1997
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/43119 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:387:y:1997:i:6636:d:10.1038_43119

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/43119

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().