From RAGs to stitches

David T. Weaver and Fredrick W. Alt
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David T. Weaver: Center for Blood Research
Fredrick W. Alt: Center for Blood Research

Nature, 1997, vol. 388, issue 6641, 428-429

Abstract: V(D)Jrecombination is used by lymphocytes to assemble the variable regions of antigen receptors. It involves the formation of a DNA double-strand break, followed by rejoining of the blunt DNA ends. Studies of the breakage and rejoining reactions will be facilitated by the development of a new, cell-free system in mammalian cells, and the identification of a hitherto undiscovered component of this system in yeast.

Date: 1997
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DOI: 10.1038/41225

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