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Life and death in a FLASH

Jan Paul Medema ()
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Jan Paul Medema: Leiden University Medical Center

Nature, 1999, vol. 398, issue 6730, 756-757

Abstract: There are many similarities between nematodes and mammals in the pathways that lead to programmed cell death. There are also differences, and one of these is now highlighted -- it seems that mammals have an extra level of complexity. A protein called FLASH has been shown to modulate the activity of a killer protease (caspase), and even its existence was completely unexpected.

Date: 1999
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DOI: 10.1038/19638

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