A microRNA polycistron as a potential human oncogene

Lin He, J. Michael Thomson, Michael T. Hemann, Eva Hernando-Monge, David Mu, Summer Goodson, Scott Powers, Carlos Cordon-Cardo, Scott W. Lowe, Gregory J. Hannon () and Scott M. Hammond ()
Additional contact information
Lin He: Watson School of Biological Sciences
J. Michael Thomson: University of North Carolina
Michael T. Hemann: Watson School of Biological Sciences
Eva Hernando-Monge: Memorial Sloan-Kettering Cancer Center
David Mu: Watson School of Biological Sciences
Summer Goodson: University of North Carolina
Scott Powers: Watson School of Biological Sciences
Carlos Cordon-Cardo: Memorial Sloan-Kettering Cancer Center
Scott W. Lowe: Watson School of Biological Sciences
Gregory J. Hannon: Watson School of Biological Sciences
Scott M. Hammond: University of North Carolina

Nature, 2005, vol. 435, issue 7043, 828-833

Abstract: MicroRNA in cancer MicroRNAs are regulatory, non-coding RNAs about 22 nucleotides in length: over 200 have been identified in humans, and their functions are beginning to be pinned down. It has been suggested that like other regulatory molecules they might be involved in tumour formation, and three papers in this issue confirm that this is the case. One cluster of microRNAs, known as mir-17–92, is shown to be a potential oncogene by its action in an in vivo model of human B-cell lymphoma. A cluster of microRNAs on human chromosome 13 has been found to be regulated by c-Myc, an important transcription factor that is overexpressed in many human cancers. And analysis of microRNA expression in over 300 individuals shows that microRNA profiles could be of value in cancer diagnosis. There is a global downregulation of microRNA in tumours, and the microRNA profile also reflects the origin and differentiation state of the tumours.

Date: 2005
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature03552 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:435:y:2005:i:7043:d:10.1038_nature03552

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature03552

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().