Lysyl oxidase is essential for hypoxia-induced metastasis

Janine T. Erler, Kevin L. Bennewith, Monica Nicolau, Nadja Dornhöfer, Christina Kong, Quynh-Thu Le, Jen-Tsan Ashley Chi, Stefanie S. Jeffrey and Amato J. Giaccia ()
Additional contact information
Janine T. Erler: Department of Radiation Oncology
Kevin L. Bennewith: Department of Radiation Oncology
Monica Nicolau: Department of Surgery
Nadja Dornhöfer: University of Leipzig
Christina Kong: Stanford University School of Medicine
Quynh-Thu Le: Department of Radiation Oncology
Jen-Tsan Ashley Chi: Duke University
Stefanie S. Jeffrey: Department of Surgery
Amato J. Giaccia: Department of Radiation Oncology

Nature, 2006, vol. 440, issue 7088, 1222-1226

Abstract: Hypoxia in tumours Tumours contain areas of low oxygen (hypoxia) because cancer cells grow and divide so fast that the blood vessels can't keep up with their oxygen requirement. Cells in a hypoxic region are prone to metastasis, but the reasons for this are unknown. Erler et al. have now discovered high levels of the enzyme lysyl oxidase (LOX) in hypoxic cells. High LOX content was associated with a poor prognosis in breast cancer patients. In mice, LOX inhibition reduced metastases, suggesting that it is a possible therapeutic target.

Date: 2006
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DOI: 10.1038/nature04695

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