Long-term gene silencing by RNAi

Nadine L. Vastenhouw, Karin Brunschwig, Kristy L. Okihara, Fritz Müller, Marcel Tijsterman and Ronald H. A. Plasterk ()
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Nadine L. Vastenhouw: Hubrecht Laboratory–KNAW, University of Utrecht, Uppsalalaan 8
Karin Brunschwig: Institute of Zoology, University of Fribourg, Pérolles
Kristy L. Okihara: Hubrecht Laboratory–KNAW, University of Utrecht, Uppsalalaan 8
Fritz Müller: Institute of Zoology, University of Fribourg, Pérolles
Marcel Tijsterman: Hubrecht Laboratory–KNAW, University of Utrecht, Uppsalalaan 8
Ronald H. A. Plasterk: Hubrecht Laboratory–KNAW, University of Utrecht, Uppsalalaan 8

Nature, 2006, vol. 442, issue 7105, 882-882

Abstract: Hard-wired RNAi An important factor that will determine the therapeutic potential of RNA interference (RNAi) is the longevity of its inhibitory effect. Previously the inheritance of RNAi induced transcriptional silencing was demonstrated for one generation in mice. Now a single RNAi episode in the nematode Caenorhabditis elegans is shown to induce transcriptional silencing that is inherited indefinitely over generations of sexual reproduction, in the absence of the trigger and of RNAi machinery.

Date: 2006
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DOI: 10.1038/442882a

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