Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses

Sheli R. Radoshitzky, Jonathan Abraham, Christina F. Spiropoulou, Jens H. Kuhn, Dan Nguyen, Wenhui Li, Jane Nagel, Paul J. Schmidt, Jack H. Nunberg, Nancy C. Andrews, Michael Farzan and Hyeryun Choe ()
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Sheli R. Radoshitzky: Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
Jonathan Abraham: Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Christina F. Spiropoulou: Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Jens H. Kuhn: Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
Dan Nguyen: Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Wenhui Li: Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
Jane Nagel: Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
Paul J. Schmidt: Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Jack H. Nunberg: Montana Biotechnology Center, The University of Montana, Missoula, Montana 59812, USA
Nancy C. Andrews: Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Michael Farzan: Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
Hyeryun Choe: Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA

Nature, 2007, vol. 446, issue 7131, 92-96

Abstract: Viral receptor identified The transferrin receptor 1 (TfR1) has been identified as the cellular receptor for four New World arenaviruses — the Junin, Machupo, Guanarito and Sabia viruses. This class of arenaviruses is important because they cause fatal haemorrhagic fevers. Treating cultured cells with an antibody against TfR1 blocks viral entry and replication. Antibodies that limit arenavirus replication without interfering with host iron metabolism may be effective in controlling outbreaks of New World haemorrhagic fever.

Date: 2007
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DOI: 10.1038/nature05539

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